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The SUSTAIN-7 trial (40 weeks comparing semaglutide 0.5 mg and 1 mg to dulaglutide) reported no confirmed pancreatitis cases in either semaglutide arm during the maintenance phase, though the trial was not powered for this endpoint

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Its important to note that these findings come from a post-hoc analysis, meaning the original studies werent specifically designed to compare these differences

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Clinical trials have shown tirzepatide produces greater average weight loss than semaglutide at equivalent timepoints, though individual response varies based on genetic and metabolic factors

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